, Division of Pediatric Clinical Pharmacology, Children’s National Medical Center, Washington, DC, USA; Departments of Pediatrics, Integrative Systems Biology, Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children’s Hospital, Rotterdam, the Netherlands; Department of Paediatric Pharmacology, University Children’s Hospital Basel, Basel, Switzerland, United States