The hemostatic system. 1st Part

Doris Barcellona, Francesco Marongiu


The hemostatic system is a complex ancestral pathway physiologically dedicated to protect the individual from bleeding. It starts immediately after an endothelial injury. Platelets and blood coagulation act synergically to provide a strength clot able to stop bleeding. In healthy subjects, the hemostatic system is able to work to avoid an excess of fibrin formation and deposition within the blood vessels on the one hand but is ready to stop bleeding on the other. To reach this crucial objective, a fine regulation of its activity is required. In other words, all actions of the hemostatic system are under control to assure a perfect balance to maintain people distant from both Scylla (bleeding) and Charybdis (thrombosis). Fibrinolysis is a complementary defensive system essential to regulate fibrin deposition via its dissolution. It is, in turn, well controlled to avoid bleeding and thrombosis by a fine control of its inducers and inhibitors. The aim of this review is to provide a picture of global haemostasis for helping in understanding this complex topic.


primary hemostasis; platelets; blood coagulation; Vitamin K; fibrin formation; fibrinolysis

Full Text: PDF Number of abstract views: 1016 Number of PDF views/downloads: 629


N.B. All JPNIM articles are accessible in Open Access. You can access the page containing the full PDF article just by clicking on the “Full Text: PDF” link at the bottom of the abstract page. On the full article page, if the article doesn’t load properly in the PDF view window, please wait a few seconds or click on the “Download this PDF file” link.

Technical advice. If you are using Firefox and you are experiencing problems, please set the browser preferences as follows: Firefox > Preferences > Advanced > General > Accessibility > deselect "Warn me when web sites try to redirect or reload the page".

Privacy Policy. English text: Privacy Policy; Italian text: Privacy Policy.

Cookie Policy. English text: Cookie Policy; Italian text: Cookie Policy.