A possible role of GDNF expression by which cabergoline use affects corpus callosum

Georgios Mitsiakos, Anastasia Gkampeta

Abstract


A variety of malformations have been associated with cabergoline use during gestation. Recently we had a preterm male infant referred to our Neonatal Intensive Care Unit diagnosed with corpus callosum agenesis confirmed by brain ultrasound and brain magnetic resonance imaging. The mother was on medication with cabergoline, due to a pituitary prolactinoma, only for the first month of pregnancy. The exact possible mechanism by witch cabergoline may have a negative effect on corpus callosum development is still unknown. Discovery of neurotrophic brain factors has opened a new chapter in the understanding of neurogenesis and synaptic plasticity mechanisms. To our knowledge, this is the first suggestion of a possible role of glial cell line-derived neurotrophic factor (GDNF) expression on corpus callosum agenesis after the administration of cabergoline in women during pregnancy.

Keywords


corpus callosum; agenesis; cabergoline; GDNF

Full Text: PDF Number of abstract views: 115 Number of PDF views/downloads: 69

 

N.B. All JPNIM articles are accessible in Open Access. You can access the page containing the full PDF article just by clicking on the “Full Text: PDF” link at the bottom of the abstract page. On the full article page, if the article doesn’t load properly in the PDF view window, please wait a few seconds or click on the “Download this PDF file” link.

Technical advice. If you are using Firefox and you are experiencing problems, please set the browser preferences as follows: Firefox > Preferences > Advanced > General > Accessibility > deselect "Warn me when web sites try to redirect or reload the page".

Privacy Policy. English text: Privacy Policy; Italian text: Privacy Policy.

Cookie Policy. English text: Cookie Policy; Italian text: Cookie Policy.