Fetal programming of Parkinson’s and Alzheimer’s diseases: the role of epigenetic factors

Monica Piras, Vassilios Fanos, Alberto Ravarino, Maria Antonietta Marcialis, Laura Vinci, Maria Cristina Pintus, Gavino Faa

Abstract


In this paper, the main epigenetic factors involved in shaping the brain’s physical structure during development will be reviewed, with special emphasis on those related to Parkinson’s disease and Alzheimer’s disease in adulthood. These factors are: preterm delivery, maternal diet, trace metals, intrauterine infection, maternal stress, drugs, alcohol. Epigenetics may allow a novel therapeutic and preventive approach for neurodegeneration.

 

Proceedings of the 10th International Workshop on Neonatology · Cagliari (Italy) · October 22nd-25th, 2014 · The last ten years, the next ten years in Neonatology

Guest Editors: Vassilios Fanos, Michele Mussap, Gavino Faa, Apostolos Papageorgiou


Keywords


fetal programming; Parkinson’s disease; Alzheimer’s disease; epigenetics; neurodegeneration

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