Histological changes in neonatal sepsis

Eleonora Obinu, Vassilios Fanos, Clara Gerosa, Daniela Fanni, Cristina Loddo, Rossano Ambu, Gavino Faa


One of the most significant causes of neonatal morbidity and mortality is represented by neonatal sepsis that often manifests itself as a systemic inflammatory response syndrome (SIRS). The progression of SIRS usually leads to multiple organ dysfunction, occasionally culminating in multiple organ failure (MOF).

The loss of endothelial barrier represents the unifying lesion of multiple organs in newborns affected by sepsis and the most important pathological change responsible for the evolution toward MOF in neonates.

The aim of this study is to present the most important pathological changes occurring in neonatal sepsis.


Proceedings of the International Course on Perinatal Pathology (part of the 10th International Workshop on Neonatology · October 22nd-25th, 2014) · Cagliari (Italy) · October 25th, 2014 · The role of the clinical pathological dialogue in problem solving

Guest Editors: Gavino Faa, Vassilios Fanos, Peter Van Eyken


neonatal sepsis; MOF; endothelial damage; loss of podocytes; endothelial apoptosis

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